Decanoic acid

Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy[1][2][3].

Product Specifications

CAS Number

[334-48-5]

UNSPSC

12352211

Hazard Statement

H315, H319, H412

Target

C-Met/HGFR; Endogenous Metabolite; Glutaminase; iGluR; Tyrosinase

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Decanoic_acid.html

Purity

99.92

Solubility

DMSO : ≥ 130 mg/mL

Smiles

CCCCCCCCCC(O)=O

Molecular Formula

C10H20O2

Molecular Weight

172.27

Precautions

H315, H319, H412

References & Citations

[1]Boison D, et, al. New insights into the mechanisms of the ketogenic diet. Curr Opin Neurol. 2017 Apr;30 (2) :187-192.|[2]Chang P, et al. Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain. 2016 Feb;139 (Pt 2) :431-43.|[3]Kim S, et, al. Selective production of decanoic acid from iterative reversal of β-oxidation pathway. Biotechnol Bioeng. 2018 May;115 (5) :1311-1320.|[4]Warren EC, et al. Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling[J]. Proc Natl Acad Sci U S A. 2020 Sep 22;117 (38) :23617-23625.|[5]Yang MH, et al. Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model[J]. Cancers (Basel) . 2023 Sep 22;15 (19) :4681.