Aloenin aglycone
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM) . Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα[1].
Product Specifications
CAS Number
[59163-53-0]
UNSPSC
12352005
Target
NF-κB; NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/aloenin-aglycone.html
Solubility
10 mM in DMSO
Smiles
O=C1OC(C2=C(C)C=C(O)C=C2O)=CC(OC)=C1
Molecular Formula
C13H12O5
Molecular Weight
248.23
References & Citations
[1]Sun Y N, et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239.|[2]Sun Y N. et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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