Fenoldopam (mesylate)

Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM) . Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].

Product Specifications

CAS Number

[67227-57-0]

Product Name Alternative

Fenoldopam (methanesulfonate) ; SKF-82526 (mesylate)

UNSPSC

12352005

Hazard Statement

H302, H317, H319

Target

Apoptosis; Dopamine Receptor

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Fenoldopam-mesylate.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : ≥ 36 mg/mL|H2O : 10 mg/mL (ultrasonic)

Smiles

OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O

Molecular Formula

C17H20ClNO6S

Molecular Weight

401.86

Precautions

H302, H317, H319

References & Citations

[1]A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258 (1) :193-8.|[2]Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561.|[3]Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Cell. 2021 Feb 18;184 (4) :943-956.e18.|Biochem Biophys Res Commun. 2022 Jan 15:588:83-89.|Biomed Pharmacother. 2021 Jul:139:111500.|SLAS Discov. 2020 Sep;25 (8) :895-905.