Enitociclib
(+) -Enitociclib ((+) -BAY-1251152) is the enantiomer of Enitociclib with (+) optical rotation. Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC+ lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies[1][2].
Product Specifications
CAS Number
1610408-97-3
Product Name Alternative
(+) -BAY-1251152; (+) -VIP152; (S) -Enitociclib
UNSPSC
12352005
Target
Apoptosis; CDK; DNA/RNA Synthesis; Drug Isomer
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plus-enitociclib.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 113.3 mg/mL (ultrasonic; warming)
Smiles
COC1=C(C2=C(F)C=NC(NC3=CC(C[S@](C)(=N)=O)=CC=N3)=C2)C=CC(F)=C1
Molecular Formula
C19H18F2N4O2S
Molecular Weight
404.43
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Available Sizes
Frequently Asked Questions
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