Etrasimod

Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells.

Product Specifications

CAS Number

[1206123-37-6]

Product Name Alternative

APD334

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Etrasimod.html

Purity

99.91

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

FC(F)(F)C1=CC(COC2=CC=C(NC3=C4CC[C@@H]3CC(O)=O)C4=C2)=CC=C1C5CCCC5

Molecular Formula

C26H26F3NO3

Molecular Weight

457.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Buzard DJ, et al. Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor. ACS Med Chem Lett. 2014 Nov 4;5 (12) :1313-7.