PLCγ2 (phospho-Tyr759) rabbit pAb
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate to 1D-myo-inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],
Product Specifications
Background
Synonyms
Gene ID
5336
UniProt
P16885
Cellular Locus
Intracellular,cytosol,plasma membrane,extracellular exosome,
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized phosho peptide around human PLCγ2 (Tyr759)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IF, ELISA, IHC
Validated Applications
WB,IF,ELISA,IHC
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000; IF/ICC 1:50-200; ELISA 1:2000-20000; IHC-p 1:50-200
Molecular Weight
148kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES14068-1.pdf
Observed Molecular Weight
148 kD
Subcellular Location
Intracellular, cytosol, plasma membrane, extracellular exosome
Other Product Names
Gene ID (Human)
5336
SwissProt (Human)
P16885
Available Sizes
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