PAPA NONOate
PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C) . PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].
Product Specifications
CAS Number
146672-58-4
UNSPSC
12352211
Hazard Statement
H302
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/papa-nonoate.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NCCCN(CCC)N(O)N=O
Molecular Formula
C6H16N4O2
Molecular Weight
176.22
Precautions
H302
References & Citations
[1]Rössig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274 (11) :6823-6.|[2]N Dashti, et al. Study of the effect of PAPA NONOate on the rate of diabetic wound healing. African Journal of Biotechnology. 2014.|[3]Keefer LK, et al. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol. 1996;268:281-93.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, sealed storage, away from moisture and light
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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