PAPA NONOate

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C) . PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].

Product Specifications

CAS Number

[146672-58-4]

UNSPSC

12352211

Hazard Statement

H302

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/papa-nonoate.html

Purity

98.0

Solubility

H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NCCCN(CCC)N(O)N=O

Molecular Formula

C6H16N4O2

Molecular Weight

176.22

Precautions

H302

References & Citations

[1]Rössig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274 (11) :6823-6.|[2]N Dashti, et al. Study of the effect of PAPA NONOate on the rate of diabetic wound healing. African Journal of Biotechnology. 2014.|[3]Keefer LK, et al. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol. 1996;268:281-93.