4- (tert-Butyl) -benzhydroxamic Acid

4- (tert-Butyl) -benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4- (tert-Butyl) -benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].

Product Specifications

CAS Number

[62034-73-5]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/4-tert-butyl-benzhydroxamic-acid.html

Concentration

10mM

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C=C1)C(C)(C)C)NO

Molecular Formula

C11H15NO2

Molecular Weight

193.24

Precautions

H302, H312, H332

References & Citations

[1]Klein T, et al. Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptionalregulator PqsR: biophysically guided hit discovery and optimization. ACS Chem Biol. 2012 Sep 21;7 (9) :1496-501.