Pirarubicin (Hydrochloride)
Product Specifications
UNSPSC Description
Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.
Target Antigen
Antibiotic; Autophagy; Bacterial; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection;Autophagy;Cell Cycle/DNA Damage
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/pirarubicin-hydrochloride.html
Smiles
O=C1C2=C(C=CC=C2OC)C(C3=C(O)C4=C([C@@H](O[C@@]5([H])C[C@H](N)[C@H](O[C@@]6([H])OCCCC6)[C@H](C)O5)C[C@@](C(CO)=O)(O)C4)C(O)=C31)=O.Cl
Molecular Weight
664.10
References & Citations
[1]Takigawa N, et al. Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines. Gan To Kagaku Ryoho. 1993 May;20(7):929-35.|[2]Nagai K, et al. Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells. Cancer Chemother Pharmacol. 2002 Mar;49(3):244-50. Epub 2002 Jan 8.|[3]Li K, et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5.|[4]Wang YD, et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2017 Oct 27:1-13.AAPS PharmSciTech. 2024 Sep 7;25(7):211.|Cancer Drug Resist. 2020 Sep 12. |Heliyon. June 2022, e09643.|Int J Pharm. 2022 May 25;620:121761.|J Mol Liq. 2020, 114633.|J Mol Liq. 2023 Jun 12, 122324.|University of Paris. 2022 Sep 19.|Cancers (Basel). 2023 Apr 26, 15(9), 2487.|E3S Web of Conferences. 233, 02010 (2021).|Genomics. 2021 Nov 26;S0888-7543(21)00410-9.|Int J Biol Macromol. 2024 Apr 10;267(Pt 2):131514.|Int J Cancer. 2024 Jul 15;155(2):324-338.|Int J Hyperthermia. 2024 Feb 12;41(1):2316085.|Int J Mol Med. 2023 May 17.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Mol Med Rep. 2024 May;29(5):84.|Toxicol Appl Pharmacol. 2023 Feb 3;462:116411.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13725A/Pirarubicin-Hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13725A/Pirarubicin-Hydrochloride-SDS-MedChemExpress.pdf
CAS Number
95343-20-7
Available Sizes
Curated Selection
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