(Rac) -BMS-816336
(Rac) -BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac) -BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 10 nM and 68 nM, respectively. (Rac) -BMS-816336 has good metabolic stability[1].
Product Specifications
CAS Number
1009365-98-3
UNSPSC
12352005
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/rac-bms-816336.html
Purity
99.91
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
OC1[C@H]2C[C@@H]3[C@@](C4=CC=CC=C4)(CC(N5CC(O)C5)=O)[C@@H](CC1C3)C2
Molecular Formula
C21H27NO3
Molecular Weight
341.44
References & Citations
[1] Ye XY, et al. Discovery of Clinical Candidate 2- ((2S,6S) -2-Phenyl-6-hydroxyadamantan-2-yl) -1- (3'-hydroxyazetidin-1-yl) ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60 (12) :4932-4948.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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