Isoxazole

Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects) . For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor[1][2][3][4][5].

Product Specifications

CAS Number

[288-14-2]

UNSPSC

12352005

Hazard Statement

H225

Target

Antibiotic; ATP-binding cassette (ABC) transporters; Bacterial; Epigenetic Reader Domain; Fungal; HSP

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isoxazole.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1=CON=C1

Molecular Formula

C3H3NO

Molecular Weight

69.06

Precautions

H225

References & Citations

[1]Zhu J, et al. The recent progress of isoxazole in medicinal chemistry. Bioorg Med Chem. 2018 Jul 23;26 (12) :3065-3075. |[2]Sysak A, et al. Isoxazole ring as a useful scaffold in a search for new therapeutic agents. Eur J Med Chem. 2017 Sep 8;137:292-309. |[3]Norman BH, et al. Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1) [J]. Bioorg Med Chem Lett. 2002 Mar 25;12 (6) :883-6.|[4]Agrawal N, Mishra P. The synthetic and therapeutic expedition of isoxazole and its analogs[J]. Med Chem Res. 2018;27 (5) :1309-1344.|[5]Kalwat MA, et al. Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells. ACS Chem Biol. 2016 Apr 15;11 (4) :1128-36.