STING-IN-10
STING-IN-10 (P8) is a dual STING PROTAC degrader and inhibitor with a DC50 value of 2.58 μM in THP-1 cells. STING-IN-10 has anti-inflammatory activity[1]. (Pink: Target protein ligand ; Black: linker (HY-W123015) ; Blue: E3 ligase ligand (HY-126457) )
Product Specifications
UNSPSC
12352211
Target
PROTACs; STING
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sting-in-10.html
Smiles
O=C1CCC(C(N1)=O)N2C(C3=CC=CC(OCC4=CN(N=N4)CCCCCC(OCCC5=CC=C(C=C5)NC(C6=CC=C(O6)[N+]([O-])=O)=O)=O)=C3C2=O)=O
Molecular Formula
C35H33N7O11
Molecular Weight
727.68
References & Citations
[1]Xue L, Liu R, Zhang L, Qiu T, Liu L, Yin R, Jiang T. Discovery of novel nitrofuran PROTAC-like compounds as dual inhibitors and degraders targeting STING. Eur J Med Chem. 2024 Dec 5;279:116883.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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