CC-90003

CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.

Product Specifications

CAS Number

[1621999-82-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CC-90003.html

Purity

99.71

Solubility

DMSO : ≥ 125 mg/mL

Smiles

C=CC(NC1=CC(C)=CC=C1NC2=NC(NC3=CC(OC)=NC=C3C)=NC=C2C(F)(F)F)=O

Molecular Formula

C22H21F3N6O2

Molecular Weight

458.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Monica M. Mita, et al. A phase Ia study of CC-90003, a selective extracellular signal-regulated kinase (ERK) inhibitor, in patients with relapsed or refractory BRAF or RAS-mutant tumors. Journal of Clinical Oncology 35, no. 15_suppl (May 20 2017) 2577-2577.