α-Conotoxin GIC
Product Specifications
UNSPSC Description
α-Conotoxin GIC is a potent and selective α3β2 nicotinic antagonist with an IC50 of 1.1 nM[1].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C(CN)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H]2C)=O)CCC1)=O)CC3=CNC=N3)=O)CO)=O)CSSC[C@H](NC4=O)C(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4[C@H](CC)C)=O)CC5=CNC=N5)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)=O)C)=O
Molecular Weight
1609.79
References & Citations
[1]McIntosh JM, et al. Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors. J Biol Chem. 2002 Sep 13;277(37):33610-5.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
757236-92-3
Curated Selection
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