α-Conotoxin GIC

Product Specifications

CAS Number

[757236-92-3]

UNSPSC Description

α-Conotoxin GIC is a potent and selective α3β2 nicotinic antagonist with an IC50 of 1.1 nM[1].

Target Antigen

nAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(CN)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H]2C)=O)CCC1)=O)CC3=CNC=N3)=O)CO)=O)CSSC[C@H](NC4=O)C(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4[C@H](CC)C)=O)CC5=CNC=N5)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)=O)C)=O

Molecular Weight

1609.79

References & Citations

[1]McIntosh JM, et al. Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors. J Biol Chem. 2002 Sep 13;277(37):33610-5.