5-Iodo-indirubin-3'-monoxime

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

Product Specifications

CAS Number

[331467-03-9]

UNSPSC

12352005

Target

CDK; GSK-3

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-iodo-indirubin-3-monoxime.html

Concentration

10mM

Purity

98.12

Solubility

DMSO : 67.5 mg/mL (ultrasonic)

Smiles

O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O

Molecular Formula

C16H10IN3O2

Molecular Weight

403.17

References & Citations

[1]Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276 (1) :251-60.