Phenytoin (sodium)

Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

Product Specifications

CAS Number

[630-93-3]

Product Name Alternative

5,5-Diphenylhydantoin (sodium salt)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sodium Channel; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Phenytoin-sodium.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1N=C(O[Na])NC1(C2=CC=CC=C2)C3=CC=CC=C3

Molecular Formula

C15H11N2NaO2

Molecular Weight

274.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5 (7) : p. 553-64.|[2]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.|[3]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51 (5) : p. 1379-87.|[4]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14 (1) :13.|[5]Assaggaf MA, et al. Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice. Am J Pathol. 2015 Jun;185 (6) :1588-99.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Int Immunopharmacol. 2023 Feb:115:109706.|University of Glasgow. School of Cancer Sciences.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Oxid Med Cell Longev. 2022 Mar 28;2022:8538296.|Regen Ther. 2023 Jul 6:24:201-210.