SEMA4D Polyclonal Antibody
Product Specifications
Background
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system, induces B-cells to aggregate and improves their viability (in vitro) . Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Abbreviation
SEMA4D
UniProt
Q92854
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human SEMA4D protein expressed by Mammalian
Target
CD100; CD100 antigen; Coll 4; COLL4; Collapsin 4; Collapsin4; GR3; MSEMA; SEM4D; Sema 4d; SEMA J; Semacl2; SemaH; SEMAJ; A8; BB18; GR3
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Immunology; Neuroscience
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
96kDa
Observed Molecular Weight
120kDa-140kDa
Isotype
IgG
Available Sizes
Documents
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