MC-VC-PAB-Cyclohexanediamine-Thailanstatin A
MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a Spliceostatin analog, and a drug-linker conjugates for ADC, consisting of ADC Cytotoxin Thailanstatin A (HY-129589) and cleavable ADC linker (MC-vc-PAB). MC-VC-PAB-Cyclohexanediamine-Thailanstatin A can be used for ADC synthesis[1].
Product Specifications
CAS Number
1609108-96-4
UNSPSC
12352203
Target
DNA/RNA Synthesis; Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-vc-pab-cyclohexanediamine-thailanstatin-a.html
Purity
92.11
Solubility
DMSO : 85 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@]2(C[C@H](O[C@@H]1/C=C/C(C)=C/C[C@H]3[C@H](C[C@H]([C@H](O3)C)NC(/C=C\[C@H](C)OC(C)=O)=O)C)CC(N[C@@H]4CC[C@H](CC4)NC(OCC5=CC=C(C=C5)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)=O)=O)CO2
Molecular Formula
C63H91N9O16
Molecular Weight
1230.45
References & Citations
[1]Dirico KJ, et al. Preparation of spliceostatin analog antibody conjugates for cancer treatment. World Intellectual Property Organization, WO2014068443 A1. 2014-05-08.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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