MC-VC-PAB-Cyclohexanediamine-Thailanstatin A

MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a Spliceostatin (HY-16466) analog, and a drug-linker conjugates for ADC, consisting of ADC Cytotoxin Thailanstatin A (HY-129589) and cleavable ADC linker (MC-vc-PAB) . MC-VC-PAB-Cyclohexanediamine-Thailanstatin A can be used for ADC synthesis[1].

Product Specifications

CAS Number

[1609108-96-4]

UNSPSC

12352203

Target

DNA/RNA Synthesis; Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc-vc-pab-cyclohexanediamine-thailanstatin-a.html

Purity

92.11

Solubility

DMSO : 85 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@]2(C[C@H](O[C@@H]1/C=C/C(C)=C/C[C@H]3[C@H](C[C@H]([C@H](O3)C)NC(/C=C\[C@H](C)OC(C)=O)=O)C)CC(N[C@@H]4CC[C@H](CC4)NC(OCC5=CC=C(C=C5)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)=O)=O)CO2

Molecular Formula

C63H91N9O16

Molecular Weight

1230.45

References & Citations

[1]Dirico KJ, et al. Preparation of spliceostatin analog antibody conjugates for cancer treatment. World Intellectual Property Organization, WO2014068443 A1. 2014-05-08.