Filipin II

Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L[1][2].

Product Specifications

CAS Number

[38620-77-8]

UNSPSC

12352211

Target

Antibiotic; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/filipin-ii.html

Smiles

O=C1O[C@H](C)[C@@H](O)/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)[C@H]1CCCCCC

Molecular Formula

C35H58O10

Molecular Weight

638.83

References & Citations

[1]Payero TD, et al., Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.|[2]Gao H, et al. Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-ant[J]. Rsc Advances, 2014, 4 (100) : 57267-57270.