Tyrphostin 47

Tyrphostin 47 is a nonspecific inhibitor of WNK1. Tyrphostin 47 is a protein tyrosine kinase inhibitor. Tyrphostin 47 inhibits smooth-muscle cell proliferation[1][2]

Product Specifications

CAS Number

[118409-60-2]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tyrphostin-47.html

Smiles

S=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1

Molecular Formula

C10H8N2O2S

Molecular Weight

220.25

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Erfinanda L, et al. Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. Sci Transl Med. 2022 Dec 7;14 (674) :eabg8577.|[2]Gottsauner-Wolf M, et al. Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth-muscle cell proliferation in a rat carotid balloon-injury model. Am Heart J. 1997 Mar;133 (3) :329-34.