LY334370 (hydrochloride)

LY334370 hydrochloride is a selective 5-HT1F receptor agonist with a Kd value of 0.446 nM. LY334370 hydrochlorid has anti-migraine activity[1][2].

Product Specifications

CAS Number

[199673-74-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly334370-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C=C1)F)NC2=CC3=C(NC=C3C4CCN(CC4)C)C=C2.Cl

Molecular Formula

C21H23ClFN3O

Molecular Weight

387.88

Precautions

P261-P280-P302+P352

References & Citations

[1]Wainscott DB, et al. [3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn Schmiedebergs Arch Pharmacol. 2005 Mar;371 (3) :169-77.|[2]Johnson KW, et al. 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs. Neuroreport. 1997 Jul 7;8 (9-10) :2237-40.