Aquacobalamin
Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II by HSO5- in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt (III) hydroperoxo adduct with a 0.25 mM dissociation constant[1][2][3].
Product Specifications
CAS Number
13422-52-1
UNSPSC
12352211
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/aquacobalamin.html
Smiles
O[Co+3]1234-;@[N]5=;@C6-;@C(C)=;@C(-;@C(CC(N)=O)(C)-;@C-;@7CCC(N)=O)-;@[N]-;@1=;@C7-;@C=;@C(-;@C(C)(C)-;@C-;@8CCC(N)=O)-;@[N]-;@2=;@C8-;@C(C)=;@C(-;@C(C)(-;@C-;@C-;@C(-;@N-;@C-;@C(C)-;@O-;@P(-;@O-;@C9-;@C(O)-;@C(-;@O-;@C-;@9CO)-;@N%10-;@C=;@[N]-;@4-;@C%11=;@C-;@%10-;@C=;@C(C)-;@C(C)=;@C-;@%11)([O-])=O)=O)-;@C-;@%12CC(N)=O)-;@[N-]-;@3-;@C%12-;@C-;@5(C)-;@C(CC(N)=O)(C)-;@C-;@6CCC(N)=O.[OH-]
Molecular Formula
C62H90CoN13O16P
Molecular Weight
1363.36
References & Citations
[1]Ling Xia, et al. Studies on the formation of glutathionylcobalamin: any free intracellular aquacobalamin is likely to be rapidly and irreversibly converted to glutathionylcobalamin. Inorg Chem. 2004 Oct 18;43 (21) :6848-57.|[2]Maria Lehene, et al. Adduct of Aquacobalamin with Hydrogen Peroxide. Inorg Chem. 2021 Sep 6;60 (17) :12681-12684.|[3]Ilia A Dereven'kov, et al. Aquacobalamin Accelerates Orange II Destruction by Peroxymonosulfate via the Transient Formation of Secocorrinoid: A Mechanistic Study. Int J Mol Sci. 2022 Oct 7;23 (19) :11907.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
37024121 3x 1.0µg DNA
PLOD1 CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details GTR10398645 96 Well
Human Calcineurin subunit B type 2 (PPP3R2) ELISA kit
Sign In for Pricing
View Details 
bs-0107R-Cy7-01 20 µL
Beta Amyloid 1-42 Polyclonal Antibody, Cy7 Conjugated
Sign In for Pricing
View Details bs-0107R-Cy7-02 100 µL
Beta Amyloid 1-42 Polyclonal Antibody, Cy7 Conjugated
Sign In for Pricing
View Details 