Hepcidin/LEAP-1 (Human)

<strong>Hepcidin/LEAP-1 (Human)</strong> <strong>Catalog number:</strong> MDP0759 <strong>CAS Number: </strong>954420-50-9 <strong>Sequence: </strong>Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Reported disulfide bonds between Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, and Cys14-Cys22) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 2789.2 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Al-Massadi O, Müller T, Tschöp M, Diéguez C, Nogueiras R. Ghrelin and LEAP-2: Rivals in Energy Metabolism Trends Pharmacol Sci. 2018 Aug;39(8):685-694. 2: Sang Y, Ramanathan B, Minton JE, Ross CR, Blecha F. Porcine liver-expressed antimicrobial peptides, hepcidin and LEAP-2: cloning and induction by bacterial infection Dev Comp Immunol. 2006;30(4):357-66. 3: Klüver E, Schulz A, Forssmann WG, Adermann K. Chemical synthesis of beta-defensins and LEAP-1/hepcidin J Pept Res. 2002 Jun;59(6):241-8. 4: Chen J, Lv YP, Dai QM, Hu ZH, Liu ZM, Li JH. Host defense peptide LEAP-2 contributes to monocyte/macrophage polarization in barbel steed (Hemibarbus labeo) Fish Shellfish Immunol. 2019 Apr;87:184-192. 5: Segat L, Pontillo A, Milanese M, Tossi A, Crovella S. Evolution of the hepcidin gene in primates BMC Genomics. 2008 Mar 5;9:120. 6: Mohammed I, Abedin A, Tsintzas K, Abedin SA, Otri AM, Hopkinson A, Mathew M, Dua HS. Increased expression of hepcidin and toll-like receptors 8 and 10 in viral keratitis Cornea. 2011 Aug;30(8):899-904. 7: Yang G, Guo H, Li H, Shan S, Zhang X, Rombout JH, An L. Molecular characterization of LEAP-2 cDNA in common carp (Cyprinus carpio L.) and the differential expression upon a Vibrio anguillarum stimulus; indications for a significant immune role in skin Fish Shellfish Immunol. 2014 Mar;37(1):22-9. 8: van Hoek ML. Antimicrobial peptides in reptiles Pharmaceuticals (Basel). 2014 Jun 10;7(6):723-53. 9: Malyszko J, Malyszko JS, Pawlak K, Mysliwiec M. Hepcidin, an acute-phase protein and a marker of inflammation in kidney transplant recipients with and without coronary artery disease Transplant Proc. 2006 Nov;38(9):2895-8. <a href="https://pubmed.ncbi.nlm.nih.gov/21664976">10: Barnes AC, Trewin B, Snape N, Kvennefors EC, Baiano JC. Two hepcidin-like antimicrobial peptides in Barramundi Lates calcarifer exhibit differing tissue tropism and are induced in response to lipopolysaccharide Fish Shellfish Immunol. 2011 Aug;31(2):350-7. </a> <br><strong>Products Related to Hepcidin/LEAP-1 (Human) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>