Denifanstat
Denifanstat (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. Denifanstat has the potential for fatty liver disease and cancer research[1][2].
Product Specifications
CAS Number
1399177-37-7
Product Name Alternative
TVB-2640; FASN-IN-2; ASC-40
UNSPSC
12352005
Target
Fatty Acid Synthase (FASN)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fasn-in-2.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C2CCN(C(C3=CC(C4=NC(C)=NN4)=C(C5CCC5)C=C3C)=O)CC2)C=C1
Molecular Formula
C27H29N5O
Molecular Weight
439.55
References & Citations
[1]Johan D., et al. Heterocyclic modulators of lipid synthesis. WO2012122391A1.|[2]Minhyoung Lee, et al. Fatty Acid Synthase inhibition prevents palmitoylation of SARS-CoV2 Spike Protein and improves survival of mice infected with murine hepatitis virus. BioRxiv, December 21, 2020.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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