Denifanstat

Denifanstat (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. Denifanstat has the potential for fatty liver disease and cancer research[1][2].

Product Specifications

CAS Number

[1399177-37-7]

Product Name Alternative

TVB-2640; FASN-IN-2; ASC-40

UNSPSC

12352005

Target

Fatty Acid Synthase (FASN)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fasn-in-2.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(C2CCN(C(C3=CC(C4=NC(C)=NN4)=C(C5CCC5)C=C3C)=O)CC2)C=C1

Molecular Formula

C27H29N5O

Molecular Weight

439.55

References & Citations

[1]Johan D., et al. Heterocyclic modulators of lipid synthesis. WO2012122391A1.|[2]Minhyoung Lee, et al. Fatty Acid Synthase inhibition prevents palmitoylation of SARS-CoV2 Spike Protein and improves survival of mice infected with murine hepatitis virus. BioRxiv, December 21, 2020.