11β-HSD1-IN-7

11β-HSD1-IN-7 (compound c10a) is a 11β HSD1 inhibitor with an IC50 value of 1.9 μM for human 11β HSD1. 11β-HSD1-IN-7 can be used for the research of diabetes and cognitive decline[1].

Product Specifications

CAS Number

[728-86-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/11β-hsd1-in-7.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)C2=CC=C(C(F)(F)F)C=C2

Molecular Formula

C14H9F3O

Molecular Weight

250.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12 (1) :16268.