VH4127
VH4127 is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a KD of 18 nM for hLDLR. VH4127, bearing non-natural amino acid residues, specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR[1][2].
Product Specifications
UNSPSC
12352209
Target
LDLR
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/vh4127.html
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(SSC[C@@H](NC(CC)=O)C(N[C@@H](CCSC)C(N1[C@H]2CSC1)=O)=O)(C)C)C(N)=O)=O)=O)=O)[C@H](CCCNC(N)=N)NC2=O
Molecular Formula
C40H71N15O9S4
Molecular Weight
1034.35
References & Citations
[1]Xue Yang, et al. Preparation and In Vitro Validation of a Cucurbit[7]uril-Peptide Conjugate Targeting the LDL Receptor. J Med Chem. 2023 Jul 13;66 (13) :8844-8857. |[2]Angélina Acier, et al. LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma. Commun Biol. 2021 Aug 19;4 (1) :987.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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