DSM705 (hydrochloride)
DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC50=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs[1].
Product Specifications
CAS Number
2989908-08-7
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dsm705-hydrochloride.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](C1=NC=NN1)NC(C2=C(C(C3(C4=CC=C(N=C4)C(F)(F)F)CC3)=CN2)C)=O.[H]Cl
Molecular Formula
C19H20ClF3N6O
Molecular Weight
440.85
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
LINC02903 (NM_001024607) Human Over-expression Lysate
P73 (Tumor Suppressor) (P73/2531), CF488A conjugate, 0.1mg/mL
![ihog Mouse Monoclonal Antibody [Clone ID: 3G8]](https://cdn.genprice.uk/products/937/68dd189a061270361e8fbdfb/imageurl/am06460su-n.webp)
![CCN2 Mouse Monoclonal Antibody [Clone ID: OTI2C9]](https://cdn.genprice.uk/products/937/68dd18b9061270361e907f53/imageurl/cf806797.webp)