TMX-4116
TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma[1].
Product Specifications
CAS Number
2766385-56-0
UNSPSC
12352005
Target
Casein Kinase; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tmx-4116.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(N1N=NC(C2=CSC(C(N3CCCC3)=O)=C2OC)=C1)CC4)NC4=O
Molecular Formula
C17H19N5O4S
Molecular Weight
389.43
References & Citations
[1]Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65 (1) :747-756.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Calnexin (Endoplasmic Reticulum Marker) (CANX/1541), CF488A conjugate, 0.1mg/mL
Aquaporin 5 (AQP5) (C-term) Rabbit Polyclonal Antibody
![Elab Fluor® Violet 500 Anti-Mouse CD11c Antibody[N418]](https://cdn.genprice.uk/products/763/68dd149c061270361e7cf3c4/imageurl/e-ab-f0991ur.webp)
Elab Fluor® Violet 500 Anti-Mouse CD11c Antibody[N418]
Elab Fluor® Violet 500 Anti-Mouse CD11c Antibody[N418]
