UNC2250
UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.
Product Specifications
CAS Number
1493694-70-4
UNSPSC
12352005
Hazard Statement
H302
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/UNC2250.html
Purity
99.92
Solubility
0.1 M HCl : 12.5 mg/mL (ultrasonic; adjust pH to 3 with HCl) |DMSO : ≥ 10 mg/mL
Smiles
CCCCNC1=NC(N[C@@H]2CC[C@@H](O)CC2)=C(C3=CC=C(CN4CCOCC4)C=N3)C=N1
Molecular Formula
C24H36N6O2
Molecular Weight
440.58
Precautions
H302
References & Citations
[1]Zhang, W., et al., Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem, 2013. 56 (23) : p. 9683-92.|[2]Xiaodong Wang, et al. Pyrimidine compounds for the treatment of cancer.WO2013177168A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Mer
Available Sizes
Frequently Asked Questions
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