UNC2250

UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

Product Specifications

CAS Number

[1493694-70-4]

UNSPSC

12352005

Hazard Statement

H302

Target

TAM Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/UNC2250.html

Purity

99.92

Solubility

0.1 M HCl : 12.5 mg/mL (ultrasonic; adjust pH to 3 with HCl) |DMSO : ≥ 10 mg/mL

Smiles

CCCCNC1=NC(N[C@@H]2CC[C@@H](O)CC2)=C(C3=CC=C(CN4CCOCC4)C=N3)C=N1

Molecular Formula

C24H36N6O2

Molecular Weight

440.58

Precautions

H302

References & Citations

[1]Zhang, W., et al., Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem, 2013. 56 (23) : p. 9683-92.|[2]Xiaodong Wang, et al. Pyrimidine compounds for the treatment of cancer.WO2013177168A1.