PROTAC DYRK2 degrader 1
PROTAC DYRK2 degrader 1 (compound CP134) is a PROTAC degrader of DYRK2 (Red: DYRK2 inhibitor (HY-161598), black: linker (HY-42776), Blue: E3 ligase ligand (HY-10984) ) [1].
Product Specifications
CAS Number
[3061366-76-2]
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-dyrk2-degrader-1.html
Smiles
O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4C/C(C(/C(C4)=C/C5=CC=CC=C5Br)=O)=C\C6=CC=CC=C6Br
Molecular Formula
C42H43Br2N5O9
Molecular Weight
921.63
References & Citations
[1]Jian Chen, et al.Discovery of the First Potent DYRK2 Proteolysis Targeting Chimera Degraders. ACS Med. Chem. Lett. 2024, 15, 5, 659–666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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