MBED

MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs[1][2].

Product Specifications

CAS Number

123363-40-6

Product Name Alternative

9-Methyl-7-bromoeudistomin D

UNSPSC

12352005

Target

Fluorescent Dye

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mbed.html

Smiles

OC1=C(C2=C(C=C1Br)N(C3=C2C=CN=C3)C)Br

Molecular Formula

C12H8Br2N2O

Molecular Weight

356.01

References & Citations

[1]Diaz-Sylvester PL, et al. Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle. Mol Pharmacol. 2014 Apr;85 (4) :564-75.|[2]Mirko Vukcevic, et al. Downstream Effects of a RyR1 Mutation Linked to Malignant Hyperthermia on the Phenotypic and Functional Characteristic of Dendritic Cells. Volume 102, Issue 3, Supplement 1307aJanuary 31, 2012.