Enniatin A1
Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes[1].
Product Specifications
CAS Number
[4530-21-6]
UNSPSC
12352005
Hazard Statement
H301+H311+H331
Target
Apoptosis; ERK
Type
Natural Products
Related Pathways
Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/enniatin-a1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@]([C@@H](C)CC)([H])N(C)C([C@@H](C(C)C)OC(C([C@@H](C)CC)N(C)C([C@@H](C(C)C)OC([C@H](C(C)C)N1C)=O)=O)=O)=O)O[C@@](C(C)C)([H])C1=O
Molecular Formula
C35H61N3O9
Molecular Weight
667.87
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
References & Citations
Fusarium
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ERK
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