Cyclopentenylcytosine

Cyclopentenylcytosine (CPEC), a carbocyclic nucleoside analog of cytosine, is a potent inhibitor of CTP synthetase and causes depletion of CTP and dCTP pools. Cyclopentenylcytosine shows broad-spectrum (both DNA and RNA viruses) antiviral activity. Cyclopentenyl cytosine increases Gemcitabine (HY-17026) radiosensitisation in human pancreatic cancer cells. Cyclopentenylcytosine shows effective antiviral activity in the Ad5/NZW rabbit ocular replication model and shows anti-tumor activity in various tumor xenografts model. Cyclopentenylcytosine can be used for the study of infection and cancer[1][2][3][4].

Product Specifications

CAS Number

[90597-22-1]

Product Name Alternative

CPEC; NSC 375575

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis; HSV; Influenza Virus; Necroptosis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/cyclopentenylcytosine.html

Purity

99.76

Smiles

O[C@H]1[C@H](N2C(N=C(N)C=C2)=O)C=C(CO)[C@H]1O

Molecular Formula

C10H13N3O4

Molecular Weight

239.23

References & Citations

[1]Romanowski EG, Yates KA, Gordon YJ. Cyclopentenylcytosine (CPE-C) : In Vitro and In Vivo Evaluation as an Antiviral against Adenoviral Ocular Infections. Molecules. 2023 Jun 29;28 (13) :5078. |[2]Marquez VE, et al. Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties. J Med Chem. 1988 Sep;31 (9) :1687-94. |[3]Bierau J, Van Gennip AH, Leen R, Helleman J, Caron HN, Van Kuilenburg AB. Cyclopentenyl cytosine primes SK-N-BE (2) c neuroblastoma cells for cytarabine toxicity. Int J Cancer. 2003 Jan 20;103 (3) :387-92. |[4]van Bree C, et al. Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells. Br J Cancer. 2008 Apr 8;98 (7) :1226-33.