SJ-106C

SJ-106C is a SIRT inhibitor, with IC50 values of 0.59, 0.12, and 0.49 μM for SIRT1/2/3 respectively. SJ-106C can target mitochondria and inhibit the growth of DLBCL tumors[1].

Product Specifications

UNSPSC

12352005

Target

Mitochondrial Metabolism; Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sj-106c.html

Smiles

O=C([C@@H](NC(OCC1=CC=CC=C1)=O)CCCCNC(CCCCCCCCCCCC)=S)NCCCC[N+](CC)(CC)CC.[Br-]

Molecular Formula

C37H67BrN4O3S

Molecular Weight

727.92

References & Citations

[1]Jana S, et al. A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma. J Med Chem. 2024 Sep 12;67 (17) :15428-15437.