SJ-106C
SJ-106C is a SIRT inhibitor, with IC50 values of 0.59, 0.12, and 0.49 μM for SIRT1/2/3 respectively. SJ-106C can target mitochondria and inhibit the growth of DLBCL tumors[1].
Product Specifications
UNSPSC
12352005
Target
Mitochondrial Metabolism; Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj-106c.html
Smiles
O=C([C@@H](NC(OCC1=CC=CC=C1)=O)CCCCNC(CCCCCCCCCCCC)=S)NCCCC[N+](CC)(CC)CC.[Br-]
Molecular Formula
C37H67BrN4O3S
Molecular Weight
727.92
References & Citations
[1]Jana S, et al. A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma. J Med Chem. 2024 Sep 12;67 (17) :15428-15437.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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