E3 ligase Ligand 41

E3 ligase Ligand 41 (Compound SI-13) is a ligand for E3 ubiquitin ligase DCAF16. E3 ligase Ligand 41 can be connected to SLF (HY-114872) by a linker (HY-W040168) to form KB03-SLF (HY-147196) [1][2].

Product Specifications

CAS Number

[2375196-68-0]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; Ligands for E3 Ligase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-41.html

Smiles

OC(CCNC(C1=CC(NC(CCl)=O)=CC(C(F)(F)F)=C1)=O)=O

Molecular Formula

C13H12ClF3N2O4

Molecular Weight

352.69

References & Citations

[1]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15 (7) :737-746.|[2]ZHANG XY, et al. COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION. WO2020077278. 2020 April 16.