E3 ligase Ligand 41
Product Specifications
UNSPSC Description
E3 ligase Ligand 41 (Compound SI-13) is a ligand for E3 ubiquitin ligase DCAF16. E3 ligase Ligand 41 can be connected to SLF (HY-114872) by a linker (HY-W040168) to form KB03-SLF (HY-147196)[1][2].
Target Antigen
E1/E2/E3 Enzyme; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-41.html
Smiles
OC(CCNC(C1=CC(NC(CCl)=O)=CC(C(F)(F)F)=C1)=O)=O
Molecular Weight
352.69
References & Citations
[1]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.|[2]ZHANG XY, et al. COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION. WO2020077278. 2020 April 16.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169968/E3-ligase-Ligand-41-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169968/
Clinical Information
No Development Reported
CAS Number
2375196-68-0
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