Sparsentan-d5
Sparsentan-d5 is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].
Product Specifications
CAS Number
1801597-09-0
Product Name Alternative
RE-021-d5; DARA-a-d5
UNSPSC
12352005
Target
Angiotensin Receptor; Endothelin Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Solubility
10 mM in DMSO
Smiles
O=C1C2(CCCC2)N=C(N1CC3=CC(COC([2H])([2H])C([2H])([2H])[2H])=C(C4=C(C=CC=C4)S(NC5=NOC(C)=C5C)(=O)=O)C=C3)CCCC
Molecular Formula
C32H35D5N4O5S
Molecular Weight
597.78
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Murugesan N, et al. Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. J Med Chem. 2005 Jan 13;48 (1) :171-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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