URB694
URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH[1][2].
Product Specifications
CAS Number
904672-77-1
UNSPSC
12352005
Target
FAAH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/urb694.html
Solubility
10 mM in DMSO
Smiles
O=C(OC=1C=CC(O)=C(C1)C=2C=CC=CC2)NC3CCCCC3
Molecular Formula
C19H21NO3
Molecular Weight
311.37
References & Citations
[1]Carnevali L, et, al. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Sci Rep. 2015 Dec 14:5:18218.|[2]Boileau I, et, al. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase. J Nucl Med. 2014 Dec;55 (12) :1993-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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