Madecassic acid

Madecassic acid is isolated from Centella asiatica (Umbelliferae) . Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].

Product Specifications

CAS Number

[18449-41-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

COX; Interleukin Related; NO Synthase; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/madecassic-acid.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

C[C@@]([C@]([C@H](O)C1)([H])[C@]2(C)CO)(C[C@@H](O)[C@@H]2O)[C@](CC=C3[C@]4(CC[C@@](C(O)=O)(CC[C@H]5C)[C@@]3([H])[C@H]5C)C)([H])[C@]41C

Molecular Formula

C30H48O6

Molecular Weight

504.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Won JH, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaBpathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010 Feb;76 (3) :251-7.|[2]Xinming Yun, et al. Madecassic acid alleviates colitis-associated colorectal cancer by blocking the recruitment of myeloid-derived suppressor cells via the inhibition of IL-17 expression in γδT17 cells. Biochem Pharmacol. 2022.