Madecassic acid
Product Specifications
UNSPSC Description
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].
Target Antigen
COX; Interleukin Related; NO Synthase; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/madecassic-acid.html
Purity
99.79
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
C[C@@]([C@]([C@H](O)C1)([H])[C@]2(C)CO)(C[C@@H](O)[C@@H]2O)[C@](CC=C3[C@]4(CC[C@@](C(O)=O)(CC[C@H]5C)[C@@]3([H])[C@H]5C)C)([H])[C@]41C
Molecular Weight
504.70
References & Citations
[1]Won JH, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaBpathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010 Feb;76(3):251-7.|[2]Xinming Yun, et al. Madecassic acid alleviates colitis-associated colorectal cancer by blocking the recruitment of myeloid-derived suppressor cells via the inhibition of IL-17 expression in γδT17 cells. Biochem Pharmacol. 2022.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0569/Madecassic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0569/Madecassic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
18449-41-7
Available Sizes
Curated Selection
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