KO-947
KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential utility in MAPK pathway dysregulated tumors.
Product Specifications
CAS Number
1695533-89-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KO-947.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC(NN=C3C4=CC=NC=C4)=C3C=C2CN1CC5=CC=CC=C5
Molecular Formula
C21H17N5O
Molecular Weight
355.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Burrows F, et al. KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA) : AACR; Cancer Res 2017;77 (13 Suppl) :Abstract nr 5168. doi:10.1158/1538-7445.AM2017-5168.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
ERK1; ERK2
Available Sizes
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