KO-947

KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential utility in MAPK pathway dysregulated tumors.

Product Specifications

CAS Number

[1695533-89-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/KO-947.html

Concentration

10mM

Purity

99.68

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C1NC2=CC(NN=C3C4=CC=NC=C4)=C3C=C2CN1CC5=CC=CC=C5

Molecular Formula

C21H17N5O

Molecular Weight

355.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Burrows F, et al. KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA) : AACR; Cancer Res 2017;77 (13 Suppl) :Abstract nr 5168. doi:10.1158/1538-7445.AM2017-5168.