WEE1-IN-11
WEE1-IN-11 (Compound 13) is a potent CDK2 inhibitor with an IC50 of 2.0 nM. WEE1-IN-11 inhibits NCI–H446, A427, OVCAR3, C33A, and WiDr cells with IC50s of 93.9, 34.5, 86.7, 23.1, and 85 nM, respectively[1].
Product Specifications
CAS Number
2975172-98-4
UNSPSC
12352005
Target
Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wee1-in-11.html
Smiles
CN1CCN(C2=CC=C(NC3=NC=C(C4=CN=CS4)C(C5=CN=C(N6C[C@@H](F)CC6)S5)=N3)C=C2OC)CC1
Molecular Formula
C26H29FN8OS2
Molecular Weight
552.69
References & Citations
[1]Yang Y, et al. Wee1 inhibitor optimization through deep-learning-driven decision making. Eur J Med Chem. 2024 Sep 29;280:116912.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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