KCNQ1 activator-1

KCNQ1 activator-1 (compound 3) is a potent activator of KCNQ1 channel. KCNQ1 activator-1 has the potential for the research of long QT syndrome (LQTS) [1].

Product Specifications

CAS Number

[1008671-38-2]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kcnq1-activator-1.html

Purity

99.03

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1N(S(=O)(C2=CC=CC=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3

Molecular Formula

C22H23N3O4S2

Molecular Weight

457.57

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Mattmann ME, et al. Identification of (R) -N- (4- (4-methoxyphenyl) thiazol-2-yl) -1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K (v) 7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012;22 (18) :5936-5941.