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Anti-Elk1 (phospho-Se389) Antibody

Rabbit Polyclonal Antibody specific to Elk1 (phospho-Se389)

Product Specifications

Product Name Alternative

Anti-Elk1 (phospho-Se389) Rabbit Polyclonal Antibody

Gene Name

ELK1

Gene ID

311040

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=ELK1">ELK1</a>

UniProt

P19419

Cellular Locus

Nucleus.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide sequence that includes phosphorylation site of Serine 389 (P-R-S(p)-P-A) derived from human Elk1 and conjugated to KLH.

Target Antigen

ETS domain-containing protein Elk-1

Target

Elk1 (phospho-Se389)

Clonality

Polyclonal

Type

Antibody

Applications

WB, IHC

Field of Research

Phosphospecific Antibodies

Purification Method

Affinity-purified on phosphopeptide; non-phosphopeptidereactive antibodies were removed by chromatography on non-phosphorylated peptide

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). {UniProtKB:A4GTP4, PubMed:1630903, PubMed:7889942}.

Additionnal Information

Immunoblotting: use at dilution of 1:500-1:1,000. A band of ~62kDa is detected. <br><br>Immunohistochemistry: use at dilution of 1:50- 1:100. <br><br>These are recommended working dilutions. <br><br>End user should determine optimal dilutions for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/43037.pdf

Specificity

This antibody detects endogenous human, mouse, and rat Elk1 only when phosphorylated at serine 389.

Formulation

PBS (without Mg2 and Ca2 ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Buffer pH

pH 7.4

Target Background

Elk-1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

CAS Number

9007-83-4

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