Bopindolol (malonate)

Bopindolol ((±) -Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982) . Bopindolol malonate can be used for essential and renovascular hypertension research.

Product Specifications

CAS Number

[82857-38-3]

Product Name Alternative

(±) -Bopindolol (malonate)

UNSPSC

12352005

Hazard Statement

H302, H332

Target

5-HT Receptor; Adrenergic Receptor; Renin

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bopindolol-malonate.html

Purity

98.30

Solubility

10 mM in DMSO

Smiles

CC(N1)=CC2=C1C=CC=C2OCC(OC(C3=CC=CC=C3)=O)CNC(C)(C)C.O=C(O)CC(O)=O

Molecular Formula

C26H32N2O7

Molecular Weight

484.54

Precautions

H302, H332

References & Citations

[1]Harron DW, et al. Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1991 Jan;41 (1) :130-49.|[2]H Tanaka, et al. Hypotensive effect of bopindolol in pithed rats. Gen Pharmacol. 1993 Mar;24 (2) :373-5.|[3]Y Hosohata, et al. Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. Biol Pharm Bull. 1995 Aug;18 (8) :1066-71.|[4]Nagatomo T, et al. Bopindolol: pharmacological basis and clinical implications. Cardiovasc Drug Rev. 2001 Spring;19 (1) :9-24.